Success in First IVF Cycle :
I was just 19 when I got married, ours was an arranged marriage and we both are from a small village in Guntur district, Andhra Pradesh, though for our studies we stayed in hostel at Hyderabad. After our marriage we stayed separately from our family because of our jobs. My husband is 8 years elder to me and as a part of his job he had to leave the country for 2 years. I could not accompany him as his company was sponsoring only him. He came back when I was 22 years. I started thinking of having a child and being so young I thought I can be a mother anytime. One whole year passed without any success. After this unsuccessful year, I visited my family doctor alone. She referred me to Dr. Rama Devi and asked me to go along with my husband.
At this point I was feeling very isolated and depressed and thinking that I am only fighting the battle of infertility. During my first visit to the doctor Rama Devi – she explained me the technical points and emotional aspects of infertility. She gave me courage and I threw my entire burden on her shoulders. I was relieved from my worries. I was happy to know that someone is there to share my feelings and to treat my infertility. The doctor asked me and my husband to get few tests done and everything was normal. I was eager to become a mother and started preparing for an IUI cycle. We followed the protocol for 5 IUI cycles, but without any success. This time again, I was trapped in the web of tension, worry and guilt. It was my husband and the team of Dr. Rama who took the great effort to bring me into my normal state of mind.
My husband and I agreed to go for only one IVF cycle as we were both emotionally and monetarily drained. The stimulation medicines worked well and as per the embryologist my embryos were excellent. After the Embryo Transfer (ET) I just followed Dr. Rama’s advice and she and her team did their best to keep my hormone levels under control. The blood test on 11th day of ET gave a positive hope. On the 30th day post ET I saw a heart beat and that too, “two of it” and truly speaking I missed one of my heart beat. It took long for me to realize that I was pregnant. Through out my pregnancy I was under the care of Dr. Rama and her team. At full term I gave birth to my twins- a boy and a girl. God was very kind to me. Now my family is complete and it could not have been possible without the help of Dr. Rama and Her Team.
Translated into English for convenience
Name of Patient : P. Harita
Name of Spouse : Sri Babu
Name of the Patient changed to protect privacy
“Motherhood is the most invaluable possession in the nature.” Mother means the first preacher. It is through this institute “Dr. Rama’s Institute For Fertility” my dreams of attaining motherhood have been fulfilled. For which I do not understand and have means to express my gratitude to them. There are no words, language by which I can express my happiness, gratitude. I am in a state of blissfulness. It has been five years since I got married and like every other woman, I too had dreams of attaining motherhood, which did not get fulfilled until I approached Dr. Rama Madam. The instinct to procreate has been universal; it exists in all forms of life. Only in mankind this has evolved into an institute of marriage “It was because of their efforts, dedication and perseverance that has filled our lives with light made me a proud mother, thereby brining meaningfulness and fulfillment in my life as a woman.”” To me she is like a deity, when worshipped gives boon in the form of children to the childless. I owe a lot to Dr.Rama Madam. I don’t understand how to treat her for the gift she has given me. It is the most valuable gift which one can possess. She is the path of light and destination to many infertile couples. One should never forget her services rendered to infertile couples helping them to achieve their dream of parenthood.
Harita [28 yrs], Sri Babu [32yrs] are a couple who approached us for the fertility treatment in November 2007. They had a married life of 5 years.On investigations we found she had Hypothyroidism, Frozen pelvis and irregular period with length of 2-3 months. Couple was desperate to have baby at an earliest. Keeping in mind her frozen pelvis, we suggested her to go for “IVF” for which they have given consent, which was successful in first attempt.
As Given by the Patient
Success Story Of Sudha
Name of Patient : Sudha
Name of Spouse : Ashok
Name of the Patient changed to protect Privacy
I Sudha 25 years old from Medchal Village of Mehboobnagar district from Andhra Pradesh, India. I was married to Mr. Ashok, 41 years for whom it was the second marriage; his first wife is also issueless. Three years went in hope for child, but my house was without any noise of child. My husband then decided to consult a doctor. As it is a very small village, there is absolutely no medical facility. Then my brother-in-law read an article of Dr. Papolu Rama Devi in regional news papers. He suggested us to visit the doctor. We just step into Dr. Rama’s Institute for Fertility without any prior appointment. The first reception what we received had only won our heart. Counselors have explained us the procedure in detail and doctor asked us to do some test and after that the cause for infertility identified was “Azoospermia” means no sperms in semen.
Doctors and counselors made us understand and gave us option for treatment that is either ICSI [Intracytoplasmic Sperm Injection] or to take help of donor sperm. As we can not afford to go ahead with ICSI , we opted for donor sperm . HSG, shows that my tubes were patent, so we went for IUI but we did not get success till 6 cycles of IUI. Dr. Papolu Rama Devi then explained us about natural cycle IVF and she considered our case and also gave us less financial burden by lessening down her fees. In the 1st IVF cycle, though everything went well, as per the doctor my uterine lining called endometrium was not up to the mark, they cancelled my cycle. In 2nd cycle IVF, doctor gave some vaginal cream and medicine to improve my endometrial lining, oocyte pick up went well, embryo transfer was easy and 30 days post embryo transfer scan shows the positive fetal heart. At that moment I missed my heart beat. I was very delighted and happy. My whole family gathered and we conveyed heartfelt thanks to Dr. Rama and her team.
“Told to our counselor in local language Telugu, translated in English in her exact words”.
Sudha (20 yrs), Mr.Ashok (41 years) are the couple who approached us in May 2007. After all the primary investigations done the cause of infertility was identified as “Azoospermia” We advised them to go either for IVF-ICSI or for the sperm donation. They opted to go for sperm donation. We did 6 Cycles of IUI as her tubes were normal, but she didn’t conceive.
We suggested her to go for IVF , considering her financial status we started minimal stimulated cycle & in her second attempt she conceived.
Success Story Of Ramani
Name of Patient : N.Ramani
Name of Spouse : N.Phani Kumar Reddy
Name of the Patient changed to protect privacy
N.Ramani and N.Phani Kumar Reddy are a couple with secondary infertility, When they visited our hospital. All the investigations of the female are normal and the husband was having azoospermia. This is the reason the couple opted to go for donor semen sample. She conceived once with IUI cycle with donor semen and once in IVF procedure. But unfortunately she miscarried both the times in the first trimester. The couple approached our clinic finally in 2006 after unsuccessful attempts at various hospitals in vain. The couple were depressed and in a state of confusion. We whole heartedly welcomed them to avail our services to help them realize their dream of parenthood. We counseled the couple thoroughly and gave them all the psychological and emotional support which was the need and won their confidence.
Here are the lines as expressed by the lady once she conceived.
“The first day I stepped into Dr.Rama’s Institute for Fertility “ and met Dr.Rama Madam I knew that this is the right place, my destiny and all good will come. She boosted me and provided the support and confidence that was the need of the hour. Her enthusiasm, energy, involvement and dedication were a constant source of inspiration and spiritual energy which made me take up infertility as a challenge. From then on there was no seeing back, but to look forward for success patiently. Her individual interest in her patients, her involvement are to be greatly appreciated which never let me loose hope. I tried 8 cycles of IUI but only one resulted in pregnancy which was lost, but I never lost hope, Dr.Rama Devi was my constant source of inspiration and I decided not to leave hope and I will return only with a baby. I kept on running rounds to the hospital for 2 years. Finally on Doctors suggestion we opted for IVF treatment. In the second attempt of IVF, I conceived but as for bad luck the pregnancy was again uneventful. Finally in the IVth cycle of IVF, I conceived and some how this time I was more confident than ever before and knew this will be my beautiful child of tomorrow. With constant counseling and boosting of morale by Dr.Rama Devi inspite of her busy schedule my dream came true.
“My dream come true, my gift from my deity [Goddess of boon] in form of a child from Dr.Rama Madam and it was true. Now I am a proud mother of a beautiful boy of seven months. In the night when I see his eyes shine I feel the entire galaxy revolving in his eyes. Ultimately what’s there to say except that there is nothing that is impossible if we try with patience and perseverance. Patience, Perseverance and Individual attention is what they provide exclusively at Dr.Rama’s Institute for Fertility for which they are the most successful fertility centers in India and perhaps Asia.”
A Story of a Miracle Boy (Oligospermia) :
I am 34 years old and my husband; I shall refer him in my story here after as PD (Pati Dev i.e. husband). We never realized that we are issueless. Since all the time after our marriage we spent in fulfilling our family responsibilities as my PD’s family is large and he is the eldest of his six brothers and sisters. It was also our hard luck that he lost his father only after a year of our marriage. It has been a very tough journey for us with many ups and downs. We never had time to think about a child until we saw our friend’s children growing up in front of our eyes. It is hard to understand, but there re few questions, without any solutions. We left to God and thought he must have some plan for us. We never went for any treatment or even to our Gynaec to discuss the problem. The problems of our life got solved one by one- my PD’s brothers and sisters got married and settled in their lives. It was for the first time when my sister-in-law forcefully took me to Dr. Rama Devi as one of her friends conceived through her treatment. Now I am thankful to my sister-in-law for taking me there. Initially I was reluctant as we had prepared our selves to live like that. Just to make my sister-in-law happy, I went along with her. After my first consultation, I was completely satisfied with the doctor’s approach and also promised her to visit her centre on 3rd Day of my period along with my period. As I was in a hurry to be a mother now and considering my age factor and also my husband’s semen analysis reports showed severe oligospermia, we decided to go for an IVF cycle directly.
My journey towards parenthood was smooth because of Dr. Rama and her team. During my visit to her institute, I used to feel, it as my second home. She retrieved 4 eggs and 3 of them fertilized. 2 embryos were excellent and of A+ grade, while embryo was of compromised quality. She transferred all 3 embryos. I was feeling that I was pregnant on the day of transfer itself. All the members of my PD’s family treated me as if, I am kid. I enjoyed all the attention and the new “Queen- Hood” being bestowed upon me. By God’s grace and by Doctor’s effort, my test came positive and I was pregnant. All the days of my pregnancy were memorable. I was under the care of two superb hands, one of my PD and the other of Dr. Rama. My health, pregnancy and emotions were taken care by Dr.Rama, my PD and his family members. They were happy more than me. It was just a miracle and my miracle baby is now 3 years old and she is luck to have three mothers me, my sister-in-law and Dr. Rama.
PCOS (Polycystic Ovarian Disease) :
Name of Patient : Rajyalakshmi
Name of the Patient changed to protect privacy
Hi, I am Rajyalakshmi. It’s since 7 years we got married. I had irregular periods due to PCOD [Polycystic Ovarian Disease]. So, I had difficulty in giving birth to a child. I had tried taking treatment in Tamil Nadu but it wasn’t successful. Later, myself and my husband got a job in Hyderabad. So we were settled in Hyderabad.
I saw an advertisement about Dr. Rama’s Fertility clinics in the newspaper. We decided to take treatment here. All the patients who visited Dr. Rama’s Fertility clinics gave a very good opinion that the success rates are high. Initially I took five IUI cycles which was not successful. Then after analysis Dr. Rama had suggested IVF cycle. The doctors explained me clearly about the treatment. So, I had no confusion and very much ready for the treatment. I had my oocyte retrieval and embryo transfer done. Dr. Rama advised me to keep my mind cool without any stress. The doctor’s and nurses were kind and very much supportive. I never had a feeling that I was away from home. By everybody’s care and affection and by God’s grace my first IVF cycle was successful. Now I am two months pregnant with twins. Even today when I see everybody in the hospital, they enquire about my health and feel very much happy for me.
My heartful thanks to Dr. Rama Devi, Dr. Vijayalakshmi and Dr. Nirmala who had given me full support all through my treatment. I also feel happy to share my success story with all of you.
Oocyte Donation :
Name of Patient : Mrs. Anjali’s Story
Name of the Patient changed to protect privacy
I am 41 years old and had undergone three failed IVF cycles with my oocytes, with different fertility clinics in USA. We happened to attend the TANA meet i.e Telugu Association of North America and came across Dr.Rama’s Institute for Fertility representatives. They showed us a video presentation of their hospital which was very simple, impressive yet very informative and accurate. After seeing the presentation I took the email ID of the hospital and contacted them and mailed my case history. They promptly replied and considering my age and failure of 3 IVF cycles with my own oocytes advised me to go for oocyte donation.
We agreed with them and gave our consent, we sent them the possible characteristics we were looking in the donor. Lucky, the hospital found a donor matching our criterias. During all these mail transactions and phone conversations the staff of the hospital and Dr.Rama herself told me to keep a positive approach and encouraged us not to loose hope. Dr. Rama’s calm, but confident approach was very comforting and reassuring to us. We felt that we were receiving the best possible care and attention with you as our doctor.
After the donor was finalized Dr. Rama prescribed me medicines to synchronize my cycle with that of the donor and she asked me to get all the pre-investigations done at our place in USA only. This saved us a lot of time and money as we came to India just a day before the oocyte pick up procedure. The Donor was healthy and she produced mature acolytes which were inseminated with my husband’s sample. The procedure went on smoothly and all the while the doctor took great care for preparing my endometrium for the implantation. All the staff was very co-operative and kind and they never got irritated with my questions [even with my stupid questions]. The embryo transfer took on 3rd day and 3 healthy embryos were transferred.
We were waiting for the b-hCG blood report for confirmation of the pregnancy and by God’s grace and Dr. Rama’s efforts I conceived. No words were available for us to express our feelings and happiness. I completed the full term pregnancy and delivered a beautiful baby girl.
We are very thankful to Dr. Rama and her clinic staff for helping us build a complete family and fulfill our deepest desire to achieve parent hood. We cannot thank you enough for all your kindness, professionalism and determination in bringing us this miracle and making the impossible possible. The comfort and warmth offered by Dr. Rama and her staff will be remembered by us all through our lives.
Male Factor :
Going to infertility specialists is not something one can discuss easily with family and friends. It is a difficult decision to make and it means that both husband and wife have to accept reality and make a joint decision to seek advice and help.
Bhavana and I were married for 6 years and were trying to conceive from the last 2 years. After not conceiving, we decided to visit our local gynaecologist, she did all the tests and prescribed us some medicines, we tried for 6 monhts. But again were let down. Then we decided to visit a fertility specialist, I surfed the net for the top fertility specialists in Hyderabad and got the address of Dr. Rama’s Fertility clinics.
We were very impressed with the information furnished by the institute’s website and we decided to give it a try and contacted them via mail with our case details. I was really surprised by their prompt and accurate reply. They had patiently replied and answered all my questions. With the Staff’s prompt replies and planning we came down to the clinic and met Dr. Rama. Her friendly and personal attention reinstilled the hope and positive attitude in us. It was diagnosed that I was suffering from severe oligospermia with only 20% motility and Dr. Rama suggested we go for an IVF | ICSI. We gave consent for Dr. Rama’s advise and started the treatment. My wife was kept on long protocol hormonal therapy and mature oocytes were retrieved from her and the embryologists performed the ICSI procedure with my semen sample. The doctors and the staff kept reassuring and comforting us. Which helped us to maintain a positive out look. The ICSI procedure was a success and we had beautiful 4 embryos. The embryo transfer was done on the 3rd day of the oocyte pick up. We were eagerly waiting for the b-hCG report and alas ! the result was positive. The joy and happiness we witnessed on that day was un-expressible. My wife’s pregnancy went well and delivered a healthy baby boy.
Words cannot express how grateful we are to Dr. Rama and her staff for turning our dream of parenthood into a reality. Our struggles with infertility were an emotionally and physically trying time, however the warmth and personal attention felt at every office visit, and on every telephone call gave us the encouragement we needed, to never loose hope.
The staff of Dr. Rama’s Fertility clinics was a perfect blend of professionalism mixed with gentleness, kindness and compassion. Through Dr.Rama and her staff we have been blessed by a unique gift of life and we are truly thankful and grateful to Dr. Rama’s Infertility clinics.
“Thank You for helping to make what seemed like
An impossible dream come true for us”
Myself Mr. Mishra [46yrs] and my spouse Ms. Reena mishra[44yrs] have been married since 14years and planning to have kids all these years. We are residents of India, staying in USA from past many years. We consulted many gynaecologist and infertility doctors to have a solution to our problem. All our efforts are in vain. We are highly depressed and seemed as if darkness is spread in our lives. We are in search of a dawn “However long the night, the dawn will break”
In our search on the internet about various infertility clinics across the globe, who can buildup the hope and bring twilight in our lives, We found Dr. Rama’s Institute For fertility as one of the best fertility clinic in India rendering various services to infertile couples from all over the world to attain their dream of parenthood. We first approached Dr. Papolu Rama Devi through mails. The reply was so impressive. Warm welcome that we found while receiving us gave a hope and decided to take the treatment under her guidance. As my spouse is 44 years old and had multiple uterine fibroids and endometriosis, for which she had taken the treatment in other reputed clinic. Unfortunately it was uneventful. So, we decided to opt for oocyte donor along with surrogacy keeping in view of her health. As I will not be available during the treatment period due to my busy job schedule, I had my semen samples frozen. We were successful in the first IVF cycle only. When we heard about the news we are so happy and delighted and seemed as if an impossible dream come true for us.
Now she is in her 6th month of pregnancy. We look forward for the baby’s arrival in this world with huge anticipation. We long for the day when we can finally physically carry our baby in our arms and look at our baby in the eyes. The moment my wife heard the news, she busted in tears and said
“I begin to love the baby
and to anticipate her birth
as a fresh twist to a knot,
which I do not wish to untie.”
Last but not the least, for the couple who are facing a problem to have children I would like to say few words about Dr.Papolu Rama Devi and her team, “Their enthusiasm, energy, involvement and dedication were a constant source of inspiration and spiritual energy which made me take up infertility as a challenge. Her individual interest in her patients, her involvement is to be greatly appreciated which never let us loose hope. Patience, Perseverance and Individual attention is what they provide exclusively at Dr.Rama’s IVF Centres for which they are the most successful fertility center. ”
The feeling of happiness dwells for us in the gift
That is given to us by……..
History of our hospital dates back to 15 years rendering various services to infertile couple to achieve their dream of parenthood. We have all the facilities for performing advanced assisted reproductive techniques from IUI to PGD [Intra uterine Insemination to Pre implantation Genetic diagnosis]. A NRI couple Mr.Sateesh and Ms.Anjali happened to know our services through the website http://www.fertilityindia.com/ and approached us through mails. Ms. Anjali’s past history reveals that she was planning to have kids from last 6 years. She had undergone laparotomy for the removal of the ovarian cysts and undergone for 2 cycles of IVF, one in August 2008 and the other in October 2008 at USA. But unfortunately both the cycles were cancelled as the expected number of follicles did not mature and the hormonal E2 values were very low.
At this juncture, the couple approached us stating they would like to go for IVF with Oocyte donation. After going through all the investigations, this is considered as a case of POF [Premature Ovarian Failure]. This is a condition also known as Primary Ovarian insufficiency is the loss of function of the ovaries before age 40. A commonly cited trait for the diagnosis is amenorrhea, hypergonadotropinism and hypoestrogenism.She was advised to opt for oocyte donation. As her husband Mr. Sateesh is not available during the treatment period, he had his semen samples frozen. As Ms.Anjali requested to minimize her stay in India, we sent the medication that has to be taken by her through courier and asked her to take them as per the schedule under the guidance of her RE. Her menstrual cycle is coordinated with the donor cycle and asked her to be here before 4 days of oocyte retrieval. The IVF cycle went smoothly and the resultant embryos were tranfered into Anjali’s uterus. Her 21st day β-hCG value is more than 1500 IUwhich is a sign of positive pregnancy. The couple expressed their happiness and gratitude and said
“Happiness resides not in the possession and not in Gold.
The feeling of happiness dwells for us in the gift
That is given to us by Dr.Papolu Rama Devi”
Case of Bad Obstretic History [BOH]
Kaveri and Bharat is a couple who approached our clinic in the year 2006. Kaveri is 43 years old. This is a case of secondary infertility as she had one previous missed abortion. Kaveri is married since 6 years, & had recurrent urinary tract infections [UTI] and cystitis. Diagnostic Laparoscopy showed fundal fibroid and bilateral cornual block. She had one IVF cycle done at another fertility center. She conceived but unfortunately had a spontaneous bleeding, and missed abortion.She developed severe UTI. At this juncture she approached our center in the year 2007. She was very depressed and said this is the last chance that was left to her as she was exhausted.
This is a case of secondary infertility with a bad obstetric history. She was counseled to get out of the stress and to develop a positive thinking. She was kept on observation for few months to over come all the pain that she had taken both physically and psychologically. As she was suffering with intractable UTI and vaginitis, along with regular antibiotics, lactobacillus (Ecoflora 1-billion bacilli) was administered daily for a period of 3 months. She developed resistance to infections as they are natural positive bacteria which protect from infections. Vaginal douches with sour curds daily at bed time for two months release her from chronic vaginitis. Then IVF cycle with oocyte donation was done because of her age [43 years], It failed. There was a solitary fibroid (3cm*3cm) away from the endometrium, which we thought may not hinder the result so preceded IVF treatment with out myomectomy.
As there was a failure in first attempt. We removed fibroid laparoscopically before the second cycle. A continuous emotional support and counseling has made patient relaxed and positive about life.It indirectly helped her to maintain her hormone level and it was indicated in her positive test result. After one month the scan showed the presence of fetal heart and pole. She had UTI again which was taken care immediately. She was monitored carefully through out her pregnancy. In February 2009 she delivered a healthy beautiful baby boy. The couple expressed their happiness and sense of gratitude and said they cannot find words to fully express their happiness.
Premature Ovarian Failure[POF]
Hyderabad has got a mixed set of people forming a base from all regions of India. Infact Hyderabad is considered to be a transit place for the North and South of the whole of India, with Sikhs, Gujaratis, Marathis, Bengalis and others and thus couple of all cast is treated with us. Gujarati couple Mr & Mrs. Patel visited us two years back, with a married life of 14 years. Mrs.Patel is a candidate of primary ovarian failure [POF] and they never had any fertility treatment before. She comes from joint family and never thought for a child until she became alone at home, after children of her in law’s side went for higher study. This was the reason given by her during her counseling. “Egg donation” was the treatment option for her and for that she readily agreed, as she wants to become mother at the earliest. Two IVF cycles went without success. In her third cycle, she conceived with the triplets and she went for fetal reduction. Twin pregnancy was progressing well, but unfortunately she developed high fever and she lost her precious pregnancy. After that one more cycle she underwent without success. she has given up a hope and was mentally prepared to live issueless. She visited us just to say, she is withdrawing from the program. Dr.Papolu Rama Devi advised her to take one chance and she felt a ray of hope once again. We carefully followed her at every step of treatment and counseled her during the treatment. Embryo transfer was successfully done with good command over hormone level and uterine condition was apt. β-HCG level was rising after 12th day and it was more than 1500 mIU/ ml on 30th day after embryo transfer. She had a twin sac with fetal heart and fetal pole. She is now in her 12th week of pregnancy. Her whole family is happy for her and they all wished us with lots of gratitude.
IVF miracle with Poor Ovarian Reserve
Fatima and Mohamed is a couple who approached our clinic in the year 2006. This is a case of primary infertility. The couple is 31 years and 36 years respectively with married life of 8 years. She has a problem of irregular menstrual cycle and PCOS. Polycystic ovarian syndrome (PCOS) is an endocrine disorder that affects approximately 5% of all women. This is the most common hormonal disorder among women of reproductive age, and is a leading cause of infertility.As a treatment for PCOS she underwent ovarian drilling through laparoscope, which reduces total number of follicles and if male hormone levels are more that also comes down with this procedure. After laparoscopy, ovulation induction drugs were prescribed followed by the follicular study. At the time of ovulation, they were advised timing of coitus[TOC] for 3 months. Some how TOC & IUI did not result in pregnancy.
Fatima underwent two cycles of IVF. In the first cycle inspite of good follicular recruitment, only one oocyte [Egg] was retrieved and it went unfertilized. The couple was abandoned. Empty follicular syndrome was the result of the second ovulation induction program. Couple were counseled and with their consent third IVF cycle was done with a gap of 2 years, as they left to abroad for job. In this cycle we retrieved four number of oocytes with three good quality embryos. 12th day post embryo transfer, β-hCG a pregnancy hormone indicates the positive outcome, which was confirmed after observing fetal heart on USG. Couple was exited to see the heart beat on scan and they had tears out of joy.
Luck with antagonist protocol
Vijayakumari a 33 years old lady visited us with two ‘long Protocol’ IVF fail cycle. Looking at her age,FSH and LH value we decided to go for ‘Antagonist Protocol’. This protocol is giving good results in poor ovarian reserve, high FSH, women above 34 years to 38 years. Reaserch shows that it may give better ovarian response in patients with low ovarian reserve that is women of age more than or equal to 38 years. Oocyte pickup, fertilization and development of embryo were up to the mark. Every event of IVF procedure went with out any obstacle. Luteal phase support was given and monitored for the hormone level. USG report indicates positive sigh of pregnancy with twins. Now she is in her 13th week of pregnancy. She said her joy is also double with twin pregnancy. She feels that it is a gift of God and God gave us this beautiful gift to her through us. She is now counselor in her own way, she councelles her co-patient and says “Never loose hope”.
Ovarian Hyper Stimulation [OHSS]
A couple by name Ms.Sana and Mr.Hamid’s is a case of primary infertility. Sana is 34 years old and Hamid 47 years. They had a married life of 7 years. During the journey to attain their dream of parenthood they consulted many fertility centers and under gone various lines of treatment. But all their efforts were in vain.During this line of treatment they approached our center in the year 2007. They planned to go for IVF treatment directly keeping in view of their ages and as they were desperate to have child.
Mr.Hamid’s investigations showed normal semen analysis parameters and sperm function test. Sana’s laparoscopy report showed bilateral PCOS. So during her treatment period, she was kept under careful observation to prevent OHSS [Ovarian Hyper Stimulation]. Antagonist was administered to prevent premature luteinization. But unfortunately she had a failed IVF cycle. We analyzed that her natural killer cells were high during the post embryo transfer period. Because of which it could have led to pre-implantation failure. At the same time her base line hormones FSH and LH are also high even after the treatment with medications they cannot be brought under control. At this stage she was suggested to opt for Oocyte donation for which the couple gave their consent. We gave them the option either to bring their own oocyte donor or the donor provided by the organization. We follow strict criteria as per ICMR guidelines for selection of donor. In this the donor oocytes are fertilized with the husband sperms and the resultant embryos are transferred into the Sana’s uterus [womb]. She conceived in the second cycle itself and now has a healthy ongoing pregnancy of 12 weeks. Her Glucose tolerance test is normal. She developed urinary tract infection for which she was administered medicines which is safe during pregnancy.
Success in First cycle
Sridhar[35years] & Geeta [33 years] visited us in very 2008. They had 4½ years married life and tried for a child soon after their marriage. They never used any family planning method. This was couple’s first visit to our fertility clinic. Investigation reports and other primary tests results were normal. At primary level the case can be categorized as unexplained Infertility.Couple was explained and counseled for different ART (Assisted Reproductive Technology) treatments and as a ladder approach, couple underwent three IUI cycles, but no success.
IVF cycle was planned & pretreatment parameters were checked. COH ( Controlled ovarian hyper stimulation) resulted in good follicular recruitment and had 4 good quality of embryos to transfer. Hormone levels were under control during follicular phase and luteal phase. Success knocked the door finally. 12 days post ET and 30 days post ET had a positive outcome for pregnancy hormone& fetal heart beat of fetus makes all of us happy and joyful.
A couple by name Saroja and Venkat Rao, aged 36 and 40 year old approached us to solve their problem of infertility. They have been married since 12 years. All these years they were trying with various doctors and different alternative medicines. None of them resulted into pregnancy. Almost they lost hope. At that crux of movement, they came to know about our institution.
We have gone through the past record. As a conclusive line of treatment, we performed necessary investigations. Husband’s semen analysis report shows below normal levels. As there was no surgical condition, he was advised to take care of healthy life style and put him on nutritional supplements and few medicines for 3 months. After 3 months the parameters improved a lot. But wife’s baseline FSH and LH were more and indicating ovulation is not possible. After scientific explanation about age and ovulation, they understood well and need of egg donation. They understood all aspects of oocyte donation and IVF. They were successful in the very first cycle.
Name of the Patient : Ms.Rani
Name of the Spouse : Mr.Satish
Name of the Patient changed to protect privacy
Ms.Rani and Mr.Satish is a couple stepped into our clinic in the year 2008. Ms.Rani is 38 years old and Mr.satish is 39 years with a married life of 8 years.The Priliminary investigations required to identified the cause of infertility were done in which She is identified PCOS. Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects approximately 5% of all women. It occurs amongst all races and nationalities, is the most common hormonal disorder among women of reproductive age, and is a leading cause of infertility. Mr. Satish semen analysis report was normal. She had undergone the basic line of treatment that is Timing of coitus and Intrauterine Insemination, but they failed to attain their dream of parenthood. The couple is desperate to have a kid.
After referring all her history through out the journey of infertility, the couple is advised to opt for egg donation. It is a case of poor ovarian reserve, base line FSH and her age is border line for self production of oocytes. The couple understood the scientific truth and compromised to go ahead of oocyte donation of IVF cycle. OD-ART was done. On 13th day post embryo transfer her β-hCG vale showed a positive result and the presence of fetal heart and pole in the USG. Now she is 12 weeks pregnant. They said “Our dream of parenthood came into reality and we are filled with unlimited joy and happiness”.
Presence of Endometrioma
Name of the Patient : Mrs.Meena
Name of the Spouse : Mr. Ramesh
Name of the Patient changed to protect privacy
Mrs.Meena [30 years] and Mr. Ramesh [35 years] have been married since 7 years. They first consulted us in the year 2006. We proceeded with all necessary infertility workup [investigations]. Mr.Ramesh’s semen analysis report showed Azoospermia, testicular biopsy results revealed as “maturation arrest”. Meena’s report showed the presence of Endometrioma [Collection of menstrual blood in the ovary] in the left ovary. That has been removed through laparoscopy.She had few cycles of IUI with donor sperm, but she did not conceive. She also had a cycle of IVF in May 2007. She had a weak positive pregnancy, which later terminated. After the abortion, scan shows a polyp in the endometrium. Polypectomy was done through hysteroscopy in October 2008. In the second cycle IVF she conceived. We all felt a sigh of relief. Finally whole team felt excited, as couple had a positive result. Meena believes that she deserves love of child and joy of motherhood. She wants to feelevery step of her gestational period and the bondage develops by nature. To be pregnant is to be vitally, alive, thoroughly women and undoubtedly inhibited.
History of both Male & Female Infertility
Name of the Patient changed to protect privacy
Mr and Ms. Prashanth is the couple who spent 5 years going through different fertility centers before taking a chance of meeting us. Thaey saw a advertisement about a workshop conducted by Dr. Rama’s Institute For Fertility and consulted us through phone. As the couple were quite nervous, we had special counseling session to make them free and feel homely. We were with them from the beginning of the process and guided them through out the treatment.Investigative reports reveals that this is a case of male anf female infertility. Cause of infertility is severe oligospermia with abnormal sperm morphology and PCOS ( Polycystic Ovarian Syndrome) with irregular menstrual cycle. A course of medication was given to improve sperm parameters and also counseled the couple to make a choice for ICSI (Intra cytoplasmic Sperm Injection). Complete process was explained to them and took their consent. She was p[ut on controlled ovarian stimulation. When we started controlled ovarian hyper stimulation, she developed high estradiol levels. Cycle was cancelled. Double dose of gonadotrophin agonist was given to suppress the ovary more. This time her E2 was under control and final result was β-hCG positive on 21st day after ET. The couple expressed the sense of happiness and said
“Thank you for this miracle we waited so long for, and also thank you for your emotional support, constant kindness and compassion for helping us make the decision to move forward will forever be remembered.”
Now she is in her 4th month of pregnancy and it is healthy and ongoing. Down’s Syndrome
35 years old Mrs. Nishat and her husband Mr.Md.Irfan stepped into Dr.Rama’s Institute for Fertility, in the year 2007. Mrs. Nishat is a software engineer by profession and Mr Irfan is a general physician. She is a patient with secondary infertility as she had a history of repeated abortions.
Previous Case History:
Mrs Nishat with a married life of 12 years conceived naturally in the year 1997-, but unfortunately had abortion in her 3rd month of pregnancy, D&C was done. In 1998 again she was pregnant. As she had abruptive placenta LSCS was done. She delivered a premature baby. The baby died after 3hrs of LSCS. Both her fallopian tubes were blocked with Adhesions. laparoscopy was done. Later on for 5 long years she had no history of pregnancy. For the first time in 2005 she consulted an infertility clinic in Bangalore. There she had 2 cycles of IVF done, but unfortunately she did not conceive.
Treatment at Dr.Rama’s Institute for Fertility:
The couple approached Dr.Papolu Rama Devi, in the year of 2007. When we proceeded with chromosomal analysis of both the couple (As she had repeated miscarriages) Mrs.Nishat report showed that she is a carrier of Down’s syndrome. Her investigation reports also showed TORCH infection which can be the reason for the failed IVF cycles. We suggested her to go for PGD (Preimplantation genetic Diagnostics) along with surrogate mother transfer as her endometrium is not favoring her to carry the pregnancy due to repeated miscarriages.
She was started with “Minimum stimulation Protocol”. Continuous monitering for her hormonal status and ovarian follicular development was done. Simultaneously the surrogate’s menstrual cycle was correlated with Mrs.Nishat’s menstrual cycle. Her Endometrium and hormone levels are monitored continuously. Once the mature follicle reached >18mm size and her hormonal values (Estradiol, Leutinizing hormone) was opt, hCG injection was administered. Oocyte retrieval was done after 35hrs of hCG injection. We retrieved 8 oocytes, which we fertilized with her husband sperm. 6 good quality embryos were developed, which were proceeded with PGD. In PGD single blastomere from 6-8 cell embryos were taken and analyzed genetically through FISH. Two blastomeres showed the presence of Trisomy 21(Down’s syndrome, or Down’s syndrome trisomy 21, or trisomy G is a chromosomal disorder caused by the presence of all or part of an extra 21st chromosome). Out of 4 embryos 2 developed into blastocyst that were genetically intact and free of the Trisomy 21 were transferred into the surrogate uterus. On the 21st day from the Embryo transfer the blood test (β-hCG) report showed >1500miu/ml, which is an indication of positive sign of pregnancy. The ultrasound scan report showed the presence of fetal heart and pole. After completion of 36 weeks of gestational period the surrogate mother delivered a healthy baby boy.
The couple was so excited after seeing the baby and broken down in to tears. They expressed their happiness and gratitude and as “We want to say “Thank you “from the bottom of our heart. Because of Dr Rama’s experience and expertise and advances in reproductive technology made it possible which we thought it will never happen. We are now proud parents and recommend the infertile couple to take help of Dr.Rama’s service to convert their dream into reality”.
Success with Frozen Embryo transfer
Mr. Kamal & Mrs. Sudha have been trying for kids since five years, before they approached Dr.Papolu Rama Devi. Mrs. Sudha, 28 yrs is a bank employee & Mr. Kamal, 32yrs is a software engineer by profession. Both the couple sound in a good health. In initial years of marriage, couple had difficulty in married life which corrected through hymenectomy. They wanted to complete their family fast, and had tried for that for one year.
At this stage they approached Dr.Rama’s Institute For Fertility (DRIFF) for the treatment and guidance. IUI cycles did not result in positive outcome and couple decided for IVF. Pre IVF cycle investigations revealed “Hypothyroidism” for Sudha, for which she was prescribed medicine. On the basis of investigative results IVF protocol selected for her which was suited for her need was “Antagonist Protocol”. Ovarian stimulation was started as per standard protocol and egg retrieval was done. Out of 7 eggs, six were fertilized and three good quality embryos were transferred into her uterus. Remaining three surplus embryos were frozen for future use with couple’s consent. Though there was no obvious reason and protocol was picture perfect, cycle was fail. To know the cause for implantation failure all the respective parameters were checked and we found that the percentage of Natural Killer cells in blood flow was more than the normal. We have given her Immunological therapy that is intravenous Immunoglobulin (IVIG) to collect the level of Natural killer cells.
In her next cycle we thawed the frozen embryos. Two embryos were reviewed well, which were transferred into Ms Sudha’s uterus. On the 21st day from the embryo transfer her β-hCG values showed > 1500 miu/ml. Mr.Kamal and Mrs.Sudha are much exited when they heard that the blood test showed a positive value of pregnancy hormone. Now Mrs.Sudha is in her 9th week of her pregnancy and she said “our story gives hope to many couples who are planning to have children and not able to conceive naturally. I highly recommend Dr.Rama’s Institute for Fertiltiy, it’s a supportive and wonderful place with great staff and worth the investment of time and money. No matter what happens we will feel empowered and healthier than ever. “GOOD LUCK to Every One “