Many couples experiencing male factor infertility may choose to undergo donor insemination for IUI or IVF procedures in order to achieve pregnancy.
Indication for sperm donation:
1. If there are significant abnormal semen characteristics
2. Irreversible azoospermia
3. A previous vasectomy
4. Previous radiation or chemotherapy treatment or another irreversible male fertility factor
5. Carriers of a known hereditary or genetic disorder
6. If the female is Rh sensitized and the male is Rh positive
7. Single women who desire pregnancy.
creening – Anonymous donors :-
– A thorough medical history of the donor and his family
– Donors should be between 21 to 45 years – preferably have established fertility
– Genetic screening for common diseases, Rh factor, hepatitis B & C, HIV and other STDs.
– Donors physical traits, personal habits, education, hobbies, talents, height and weight and a complete semen analysis.
[ If recipients wish to match certain characteristics – our sperm bank will provide the necessary information.]
Screening – known donors :-
Sometimes couples wish to use a known donor or a relative of the husband. Criteria for screening of known donor will be same as described above
Procedure followed before acceptance as a donor :
Young , healthy men between ages of 21 to 45 years are eligible as semen donor. Before selecting a person as a donor we collect bio-data which include physical health, mental health of the person, family history of diseases, educational status, screening of transferable diseases, height, colour of the skin, hair, eye. Specific tests – seminal parameters and sperm function tests, in case of a married man – details of the children.
– A complete application form with a consent of not disclosing the identity.
– In the application form donor characteristics like blood group, height, weight, complexion, occupation, education, complete semen analysis should be filled up.
– A thorough semen analysis with sperm count > 60 million with 60% motility and normal morphology.
– Screening for HIV, VDRL , Hepatitis
– He should not be a drug addicted
– Screening for any hereditary disorder & Genetic condition
Choosing the egg donor
Recipients complete a profile form listing specifics attributes they want in their donor. In addition, physical characteristics are also used in matching. Our team plays a vital role in assisting the coordinator in making appropriate matches with the donor. All matches are confidential.
Synchronisation of the menstrual cycles of the egg donor & recipient
The cornerstone of egg donation is the synchronization of the ovarian cycles of both the egg donor and the transfer cycle of the recipient. Their menstrual cycles are co-ordinated in such away that the egg recipient gets her cycle 3 – 5 days in advance to that of the egg donor. This ensures that the embryos are placed in the recipient’s womb at the optimal time for implantation. Hormonal priming especially estrogen & progesterone combination is given to prepare the uterus for implantation of the embryos.
When both the donor and the recipient are regulated, the donor starts the fertility medication (gonadoptropin injections) to stimulate her ovaries to produce eggs. The recipient will start her estrogen replacement prior to the donor starting her medications. While the donor is receiving the medication to mature her follicles, the estrogen the recipient is taking will prepare the lining of her uterus so it will be able to receive the embryos. Progesterone hormone is given to the recipient on the day of the egg retrieval for the donor.
The eggs are fertilized in the manner that offers the best chance of success. The method of fertilization (conventional versus ICSI) is agreed upon by the couple prior to insemination taking place.
Three or five days after the retrieval, the embryos are placed in the recipient’s uterus. The number of embryos transferred depends on the age of the donor and the quality of the embryos on the day of the transfer. The decision on the number of embryos to transfer is an important one with the goal of maximizing the probability of pregnancy without the havoc of multiple gestations. After the transfer, the recipient will continue taking the hormones, and a pregnancy test will be performed in approximately two weeks. If there is a surplus of embryos and they can be cryopreserved, the couple is offered additional chances of conception. Since the woman does not need to undergo gonadotropin stimulation again, the cost is greatly reduced.